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Tosylmethyl isocyanide

Tosylmethyl isocyanide
Tosylmethyl isocyanide structure
CAS No.
36635-61-7
Chemical Name:
Tosylmethyl isocyanide
Synonyms
TOSMIC;isocyanide;Tosylmethyl isocyani;LABOTEST-BB LT00159629;TOSYLMETHYL ISOCYANIDE;Tosylmethyleisocyanide;Tosylmethyl isocyanide,98%;Tosylmethy isocyanide ,98%;p-Toluenesulfonyl Isocyanide;TosMIC Tosylmethyl Isocyanide
CBNumber:
CB5311774
Molecular Formula:
C9H9NO2S
Formula Weight:
195.24
MOL File:
36635-61-7.mol

Tosylmethyl isocyanide Properties

Melting point:
109-113 °C(lit.)
Density 
1.2721 (rough estimate)
refractive index 
1.5270 (estimate)
storage temp. 
-20°C
solubility 
water: slightly soluble
form 
Liquid
color 
Clear
Water Solubility 
insoluble
Sensitive 
Moisture Sensitive
Merck 
14,9556
BRN 
3592382
InChIKey
BBNNLJMGPASZPD-UHFFFAOYSA-N
CAS DataBase Reference
36635-61-7(CAS DataBase Reference)
FDA UNII
C35FD6OLH8
SAFETY
  • Risk and Safety Statements
Symbol(GHS) 
GHS06
Signal word  Danger
Hazard statements  H300-H311-H331-H301+H311+H331
Precautionary statements  P280h-P309-P310-P261-P280-P301+P310-P311
Hazard Codes  T,Xi
Risk Statements  23/24/25
Safety Statements  36/37-45-38-36/37/39-28A
RIDADR  UN 2811 6.1/PG 3
WGK Germany  3
21
Hazard Note  Irritant
HazardClass  6.1(b)
PackingGroup  III
HS Code  29299000

Tosylmethyl isocyanide price More Price(7)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich 188204 p-Toluenesulfonylmethyl isocyanide 98% 36635-61-7 5g $32.5 2019-12-02 Buy
Sigma-Aldrich 188204 p-Toluenesulfonylmethyl isocyanide 98% 36635-61-7 25g $133 2019-12-02 Buy
TCI Chemical T1046 p-Toluenesulfonylmethyl Isocyanide >98.0%(HPLC)(N) 36635-61-7 5g $30 2020-06-24 Buy
TCI Chemical T1046 p-Toluenesulfonylmethyl Isocyanide >98.0%(HPLC)(N) 36635-61-7 25g $94 2020-06-24 Buy
Alfa Aesar A14312 p-Toluenesulfonylmethyl isocyanide, 97% 36635-61-7 25g $120 2020-06-24 Buy

Tosylmethyl isocyanide Chemical Properties,Uses,Production

Chemical Properties

Pale yellow to light brown crystalline powder

Uses

Reagent for use in the preparation of biologically active pyrroles and imidazoles.1,2

Uses

Tosylmethyl Isocyanide is used as a synthetic reagent in the preparation of variety or biologically active heterocycles such as pyrroles and imidazoles. Tosylmethyl Isocyanide is reported to inhibit [ Fe]-hydrogenase with very high affinity.

Uses

Versatile synthon in organic chemistry, especially in the synthesis of heterocyclic Compounds.

Preparation

N-(p-Tolylsulfonylmethyl)formamide 1609:

A 3-L, three-necked, round-bottomed flask, equipped with a mechanical stirrer, a condenser, and a thermometer, was charged with sodium p-toluenesulfinate 1606 (267 g, 1.5 mol). After the addition of water (750 mL), a 34–37% solution of formaldehyde 1607 (350 mL, 378 g, ca. 4.4 mol), formamide 1608 (600 mL, 680 g, 15 mol), and formic acid (200 mL, 244 g, 5.3 mol), the stirred reaction mixture was heated at 90 C°. The sodium p-toluenesulfinate dissolved during the heating, and the clear solution was kept at 90–95 C° for 2 h. It was then cooled in an ice/salt bath with continued stirring and further cooled overnight in a freezer at 20 C°. The white solid produced was collected by suction filtration. It was washed thoroughly in a beaker by stirring with three 250 mL portions of iced water. The product was dried under reduced pressure over phosphorus pentoxide at 70 C° to provide 134–150 g (42–47%) of crude N-(p-tolylsulfonylmethyl)formamide 1609; mp 106–110 C°. This product was sufficiently pure to be used directly in the following reaction.

Purification Methods

Use an efficient fume cupboard. Purify TOSMIC by dissolving (50g) in CH2Cl2 (150mL) and passing it through a column (40x3cm) containing neutral alumina (100g) in CH2Cl2 and eluting with CH2Cl2. A nearly colourless solution (700mL) is collected, evaporated in vacuo and the residue (42-47g) of TOSMIC (m 113-114o dec) is recrystallised once from MeOH (m 116-117o dec). [Hoogenboom et al. Org Synth 57 102 1977, Lensen Tetrahedron Lett 2367 1972.] It also crystallises from EtOH (charcoal) [Saito & Itano, J Chem Soc, Perkin Trans 1 1 1986].

Tosylmethyl isocyanide Preparation Products And Raw materials

Raw materials

Preparation Products


Tosylmethyl isocyanide Suppliers

Global( 325)Suppliers
Supplier Tel Fax Email Country ProdList Advantage
Capot Chemical Co.,Ltd.
+86(0)13336195806 +86-571-85586718
+86-571-85864795 sales@capotchem.com China 19929 60
Henan DaKen Chemical CO.,LTD.
+86-371-55531817
info@dakenchem.com CHINA 21827 58
Henan Tianfu Chemical Co.,Ltd.
0371-55170693
0371-55170693 info@tianfuchem.com CHINA 22625 55
career henan chemical co
+86-371-86658258
sales@coreychem.com CHINA 30043 58
Chemwill Asia Co.,Ltd.
86-21-51086038
86-21-51861608 chemwill_asia@126.com;sales@chemwill.com;chemwill@hotmail.com;chemwill@gmail.com CHINA 23977 58
Haihang Industry Co.,Ltd
86-531-88032799
+86 531 8582 1093 export@haihangchem.com CHINA 10158 58
Hebei Guanlang Biotechnology Co., Ltd.
+8619930501651
whatsapp: +8619930501651 breeduan@crovellbio.com CHINA 2581 58
Hubei xin bonus chemical co. LTD
86-13657291602
027-59338440 linda@hubeijusheng.com CHINA 23045 58
Shandong chuangyingchemical Co., Ltd.
18853181302
sale@chuangyingchem.com CHINA 5917 58
Chengdu Feibo Pharm Technology Co., Ltd
15982321820
abby@arkpharm.com CHINA 2924 58

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View Lastest Price from Tosylmethyl isocyanide manufacturers

Image Release date Product Price Min. Order Purity Supply Ability Manufacturer
2019-12-31 Tosylmethyl isocyanide
36635-61-7
US $0.10 / KG 1KG 99.0% 1000 tons Shaanxi Dideu Medichem Co. Ltd
2018-12-15 Tosylmethyl isocyanide
36635-61-7
US $1.00 / kg 1kg 99% Customized career henan chemical co

Tosylmethyl isocyanide Spectrum


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